Research Experiences

Computational Biologist @ University of Edinburgh, under supervision of Professor Georg Kustatscher and Matthew The, Technical University of Munich

• Optimised data preprocessing tool for combining multiple large-scale MaxQuant searches on protein group-level pgFDR, which let to discovering 7000+ novel microproteins
• Implemented this tool for accurate & sensitive protein group FDR method on MaxQuant and Fragpipe database outputs with protein isoforms on ProteomeHD2 dataset curated by Professor Georg Kustatscher
• Controlled false discovery rate for feature selection in human MS-based proteomics dataset (size: 27.1 Gb)

Statistical Geneticist @ UCL Centre of Computational Biology, under supervision of Professor ZiHeng Yang and Tomas Fluori

• Developed statistical models for predictive phylogenetic analysis on blood allele frequencies provided in a small dataset.
• Implemented Bayesian MCMC algorithm to sample probability distributions in p, q, and r frequencies from Hardy-Weinberg principle.

Mathematical Biologist @ Centre for Systems Biology Edinburgh, under supervision of Professor Ramon Grima

• Developed stochastic models (stochastic simulation algorithm) & deterministic models to analyse and predict complex data patterns in mRNA decay biochemical kinetics.
• Conducted extensive research in Continuous Time Markov Chain processes for sampling functional Kolmogorov Forward Equations (chemical Master Equation).
• Applied Gibbs sampling (MCMC) and Metropolis Hastings algorithm to investigate consistent genes in the bipartite network

Previous work (View Projects for Softwares and Tools Utilized)

1. Evaluation of different False discovery rate approaches in Large-scale Proteomics Data
   Bachelor’s Thesis, supervised by Georg Kustatscher.
   Achieved an 80% (A2).
   View PDF →

2. Random Forest with Bayesian Optimisation for Heart Failure Prediction
   View PDF →

3. Using structural bioinformatics approach for GULO functionality
   Achieved a 95% (A1).
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4. Purification and Quantification of protein-DNA interactions of Minichromosome Maintenance Protein (MCM) of Pyrococcus abyssi
   Achieved a 90% (A1).
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5. DNMT1 methylates hemi-methylated CpGs but not un- methylated CpGs View PDF →